Symbol
Name
ID

Cd3e
CD3 antigen, epsilon polypeptide
MGI:88332

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Defective T cell proliferation	Decreased circulating total IgA	Abnormal circulating IgG level	Decreased circulating total IgM	Abnormal lymphocyte count	Abnormal B cell count	Decreased proportion of CD4-positive T cells	Decreased proportion of CD3-positive T cells	Lymphopenia	Reduced natural killer cell count
Disease(s) Associated with CD3E
immunodeficiency 18

Mouse Phenotypes

increased T cell apoptosis

abnormal thymus morphology

small thymus

thymus hypoplasia

increased DN3 thymocyte number

abnormal class switch recombination

abnormal T cell differentiation

abnormal CD8-positive, alpha-beta T cell differentiation

abnormal double-negative T cell morphology

increased double-negative T cell number

abnormal double-positive T cell morphology

decreased double-positive T cell number

arrested T cell differentiation

abnormal T cell number

decreased CD4-positive, alpha-beta T cell number

absent CD4-positive, alpha-beta T cells

increased central memory CD8 positive, alpha-beta T cell number

decreased CD8-positive, naive alpha-beta T cell number

absent CD8-positive, alpha-beta T cells

increased CD8-positive, alpha-beta T cell number

absent T cells

abnormal B cell morphology

abnormal T cell morphology

abnormal regulatory T cell physiology

Availability

Mouse Genotype

Cd3e^m1Btlr/Cd3e^m1Btlr

Cd3e^m2Btlr/Cd3e^m2Btlr

Cd3e^tm1.1Geno/Cd3e^tm1.1Geno

Cd3e^tm1.1Lov/Cd3e^tm1.1Lov

Cd3e^tm1Cpt/Cd3e^tm1Cpt

Cd3e^tm1Lov/Cd3e^tm1Lov

Cd3e^tm1Mal/Cd3e^tm1Mal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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